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Propofol (Diprivan®) in Pakistan

Propofol (Diprivan®)

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Diprivan®

Description

Propofol (Diprivan®) in Pakistan | Ship Mart

Intravenous Agents: Propofol (Diprivan®) in Pakistan, Ketamine, Etomidate. Propofol (Diprivan®) is the most commonly used IV general anesthetic. In lower doses, it induces sleep while allowing a patient to continue breathing on their own.
Propofol, marketed as Diprivan, among other names, is a short-acting medication that results in a decreased level of consciousness and a lack of memory for events. Its uses include the starting and maintenance of general anesthesia, sedation for mechanically ventilated adults, and procedural sedation.
Formula: C12H18O
Metabolism: Liver glucuronidation
Duration of action: ~5–10 minutes
Onset of action: 15–30 seconds
Protein binding: 95–99%
Elimination half-life: 1.5–31 hours
AHFS/Drugs.com: Monograph
Propofol, marketed as Diprivan, among other names, is a short-acting medication that results in a decreased level of consciousness and a lack of memory for events. Its uses include the starting and maintenance of general anesthesia, sedation for mechanically ventilated adults, and procedural sedation.
Strict aseptic technique must always be maintained during handling. DIPRIVAN is a single access parenteral product (single patient infusion vial) which contains 0.005% disodium edetate (EDTA) to inhibit the rate of growth of microorganisms, for up to 12 hours, in the event of accidental extrinsic contamination. However, DIPRIVAN can still support the growth of microorganisms, as it is not an antimicrobially preserved product under USP standards. Do not use if contamination is suspected. Discard unused drug product as directed within the required time limits.

Moderate to Severe Dyspareunia

Treats symptom of vulvar and vaginal atrophy due to menopause

0.5 g intravaginally in a twice-weekly (eg, Monday and Thursday) continuously or in a cyclic regimen of daily administration for 21 days followed by 7 days off

Dosing Considerations

In postmenopausal women with a uterus, a progestin should also be considered to reduce risk of endometrial cancer

Women without a uterus do not need a progestin; in some cases, however, hysterectomized women with a history of endometriosis may need a progestin

Use of estrogen-alone, or in combination with a progestin, should be with lowest effective dose and for shortest duration consistent with treatment goals and risks for the individual.

Brand

Diprivan®

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